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Article

Runx1 regulation of Pu.1 corepressor/coactivator exchange identifies specific molecular targets for leukemia differentiation therapy.

The Journal of biological chemistry - 23 May 2014

Gu Xiaorong, Hu Zhenbo, Ebrahem Quteba, Crabb John S, Mahfouz Reda Z, Radivoyevitch Tomas, Crabb John W, Saunthararajah Yogen

Abstract excerpt

Gene activation requires cooperative assembly of multiprotein transcription factor-coregulator complexes. Disruption to cooperative assemblage could underlie repression of tumor suppressor genes in leukemia cells. Mechanisms of cooperation and its disruption were therefore examined for PU.1 and RUNX1, transcription factors that cooperate to activate hematopoietic differentiation genes. PU.1 is highly expressed in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24695740
DOI: 10.1074/jbc.M114.562447
PMCID: PMC4031539

Genes

RUNX1
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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