Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse.

Genes & development - 15 May 2001

Yamamoto M, Meno C, Sakai Y, Shiratori H, Mochida K, Ikawa Y, Saijoh Y, Hamada H

Abstract excerpt

FoxH1 (FAST) is a transcription factor that mediates signaling by transforming growth factor-beta, Activin, and Nodal. The role of FoxH1 in development has now been investigated by the generation and analysis of FoxH1-deficient (FoxH1(-/-)) mice. The FoxH1(-/-) embryos showed various patterning defects that recapitulate most of the defects induced by the loss of Nodal signaling. A substantial proportion of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Embryonic and Fetal Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epidermal Growth Factor

Share to Forkhead Transcription Factors

Share to Membrane Glycoproteins

Share to Neoplasm Proteins

Share to Nodal Protein

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 11358868
DOI: 10.1101/gad.883901
PMCID: PMC313795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse.PMID 11358868Read ↗

Foxh1 is essential for development of the anterior heart field.Semantic proximity Read ↗

Nodal-dependent mesendoderm specification requires the combinatorial activities of FoxH1 and Eomesodermin.Semantic proximity Read ↗

The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of nodal signaling required for organizer formation.Semantic proximity Read ↗

Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly.Semantic proximity Read ↗

Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo.Semantic proximity Read ↗

Genetic dissection of nodal function in patterning the mouse embryo.Semantic proximity Read ↗

Synergistic interaction between Gdf1 and Nodal during anterior axis development.Semantic proximity Read ↗

Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning.Semantic proximity Read ↗

Development biology. Nodal signalling gets foxy.Semantic proximity Read ↗

Cardiac and CNS defects in a mouse with targeted disruption of suppressor of fused.Semantic proximity Read ↗

Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1.Semantic proximity Read ↗

HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.