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Article

Organ-specific susceptibility of p53 knockout mice to N-bis(2-hydroxypropyl)nitrosamine carcinogenesis.

Cancer letters - 18 Jul 2006

Hirata Akihiro, Tsukamoto Tetsuya, Yamamoto Masami, Sakai Hiroki, Yanai Tokuma, Masegi Toshiaki, Donehower Lawrence A, Tatematsu Masae

Abstract excerpt

To elucidate which is the major determinant of susceptibility of p53 deficient mice, the carcinogen or the target organ, N-bis(2-hydroxypropyl)nitrosamine was administered to induce tumors in multi-organs. In a 15-week experiment, the incidences of both lung and hepatic vascular tumors were found to be significantly higher in p53 nullizygous (-/-) than in heterozygous (+/-) and wild-type (+/+) mice, indicating...

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Source

Identifiers

PMID: 16150539
DOI: 10.1016/j.canlet.2005.07.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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