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Article

Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine.

Oncology reports - 1 Oct 2007

Hirata Akihiro, Tsukamoto Tetsuya, Yamamoto Masami, Takasu Shinji, Sakai Hiroki, Ban Hisayo, Yanai Tokuma, Masegi Toshiaki, Donehower Lawrence A, Tatematsu Masae

Abstract excerpt

p53 knockout mice have been utilized for the functional analysis of p53 in carcinogenic processes and for the evaluation of the carcinogenic potential of chemicals. In this study, we established that p53 knockout mice have an elevated susceptibility to the induction of histiocytic sarcoma (HS) by N-bis(2-hydroxy-propyl)nitrosamine (BHP). p53 heterozygous (+/-) and wild-type (+/+) mice were treated with 20 or 200...

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PMID: 17786332

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Early development of histiocytic sarcomas in p53 knockout mice treated with N-bis(2-hydroxypropyl)nitrosamine.PMID 17786332Read ↗

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