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Article

Organ-dependent susceptibility of p53 knockout mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ).

Cancer science - 1 Aug 2007

Hirata Akihiro, Tsukamoto Tetsuya, Yamamoto Masami, Takasu Shinji, Sakai Hiroki, Ban Hisayo, Yanai Tokuma, Masegi Toshiaki, Donehower Lawrence A, Tatematsu Masae

Abstract excerpt

p53 knockout mice are now being frequently used to identify the carcinogenic potential of chemicals, thus it is important to precisely assess the susceptibility of the animals to various test chemicals. In the present study the susceptibility of p53 nullizygous((-/-)), heterozygous((+/-)), and wild-type((+/+)) mice to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was investigated. Mice of all three genotypes were...

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Identifiers

PMID: 17532756
DOI: 10.1111/j.1349-7006.2007.00517.x
PMCID: PMC11159812

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Source receipt: pubmed, retrieved 7 Sept 2026.

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