Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.

Carcinogenesis - 1 Oct 2000

Yamamoto M, Tsukamoto T, Sakai H, Shirai N, Ohgaki H, Furihata C, Donehower L A, Yoshida K, Tatematsu M

Abstract excerpt

Mutations of the p53 tumor suppressor gene constitute one of the most frequent molecular changes in a wide variety of human cancers. Mice deficient in p53 have recently attracted attention for their potential to identify chemical genotoxins. In this study we have investigated the susceptibility of p53 nullizygote (-/-), heterozygote (+/-) and wild-type (+/+) mice to N:-methyl-N:-nitrosourea (MNU) gastric...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens
Share to Cocarcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastric Mucosa

Share to Gene Dosage

Share to Methylnitrosourea

Share to Polymorphism, Single-Stranded Conformational

Share to Precancerous Conditions

Share to Stomach Neoplasms

Source

Identifiers

PMID: 11023548
DOI: 10.1093/carcin/21.10.1891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.PMID 11023548Read ↗

Elevated susceptibility of the p53 knockout mouse esophagus to methyl-N-amylnitrosamine carcinogenesis.Semantic proximity Read ↗

High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele.Semantic proximity Read ↗

High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine.Semantic proximity Read ↗

High susceptibility of nullizygous p53 knockout mice to colorectal tumor induction by 1,2-dimethylhydrazine.Semantic proximity Read ↗

Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium.Semantic proximity Read ↗

Effect of intragastric application of N-methylnitrosourea in p53 knockout mice.Semantic proximity Read ↗

Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing.Semantic proximity Read ↗

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene.Semantic proximity Read ↗

Rare mutations of p53, Ki-ras, and beta-catenin genes and absence of K-sam and c-erbB-2 amplification in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach cancers.Semantic proximity Read ↗

DNA repair and cancer: lessons from mutant mouse models.Semantic proximity Read ↗

Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice.Semantic proximity Read ↗

Alkylpurine-DNA-N-glycosylase knockout mice show increased susceptibility to induction of mutations by methyl methanesulfonate.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.