Article
Susceptibility of liver proliferative lesions in heterozygous p53 deficient CBA mice to various carcinogens.
The Journal of veterinary medical science - 1 Jul 2002
Uehara Takeki, Kashida Yoko, Watanabe Takao, Yasuhara Kazuo, Onodera Hiroshi, Hirose Masao, Mitsumori Kunitoshi
Abstract excerpt
To investigate the liver tumorigenic sensitivity to various carcinogens in heterozygous p53 deficient [p53 (+/-)] CBA mice and their wild-type littermates [p53 (+/+) mice], 71 p53 (+/-) and 74 p53 (+/+) CBA mice (male, 6-12 weeks of age) were given diet containing 4,000 or 0 ppm flumequine (FL) for 26 weeks or a single intraperitoneal injection of 5 mg/kg body weights dimethylnitrosamine (DMN) at start of the...
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