Article
Enhancement of urinary bladder carcinogenesis in nullizygous p53-deficient mice by N-butyl-N-(4-hydroxybutyl)nitrosamine.
Cancer letters - 29 Jan 1999
Yamamoto S, Min W, Lee C C, Salim E I, Wanibuchi H, Sukata T, Fukushima S
Abstract excerpt
We recently reported p53 mutations to be frequent in mouse invasive urinary bladder carcinomas, with and without metastasis. However, the role of p53 dysfunctions during carcinogenesis remains unclear. In the present study, heterozygous and nullizygous p53-deficient mice and their littermates were treated with the urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), at a concentration of...
Topics
- Animals
- Butylhydroxybutylnitrosamine
- Carcinogenicity Tests
- Carcinogens
- Carcinoma in Situ
- Carcinoma, Transitional Cell
- Cocarcinogenesis
- Gene Deletion
- Genes, p53
- Genotype
- Male
- Mice
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational