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Article

Elevated susceptibility of the p53 knockout mouse esophagus to methyl-N-amylnitrosamine carcinogenesis.

Carcinogenesis - 1 Sept 2002

Shirai Norimitsu, Tsukamoto Tetsuya, Yamamoto Masami, Iidaka Takeshi, Sakai Hiroki, Yanai Tokuma, Masegi Toshiaki, Donehower Lawrence A, Tatematsu Masae

Abstract excerpt

Mutations of the p53 tumor suppressor gene constitute one of the most frequent molecular changes in a wide variety of human cancers, including those in the esophagus. Mice deficient in p53 have recently attracted attention for their potential to identify chemical genotoxins. In this study we investigated the susceptibility of p53 nullizygous (-/-), heterozygous (+/-) and wild-type (+/+) mice to...

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Source

Identifiers

PMID: 12189199
DOI: 10.1093/carcin/23.9.1541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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