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Article

Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis.

International journal of molecular sciences - 18 Aug 2017

Kakehashi Anna, Ishii Naomi, Okuno Takahiro, Fujioka Masaki, Gi Min, Wanibuchi Hideki

Abstract excerpt

The role of deficiency of oxoguanine glycosylase 1 (Ogg1) Mmh homolog, a repair enzyme of the 8-hydroxy-2'-deoxyguanosine (8-OHdG) residue in DNA, was investigated using the multiorgan carcinogenesis bioassay in mice. A total of 80 male and female six-week-old mice of C57BL/6J background carrying a mutant Mmh allele of the Mmh/Ogg1 gene (Ogg1-/-) and wild type (Ogg1+/+) mice were administered N-diethylnitrosamine...

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Identifiers

PMID: 28820464
DOI: 10.3390/ijms18081801
PMCID: PMC5578188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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