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Article

High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N, N-dibutylnitrosamine.

Cancer letters - 8 May 2003

Nishikawa Takayuki, Salim Elsayed I, Morimura Keiichirou, Kaneko Masahiro, Ogawa Motome, Kinoshita Anna, Osugi Harushi, Kinoshita Hiroaki, Fukushima Shoji

Abstract excerpt

In human cancer, alterations in the p53 tumor suppressor gene are the most common genetic alterations. The aim of the present study was to detect sensitivity of the p53 (+/-) mice and their littermates p53 (+/+) mice to N, N-dibutylnitrosamine (DBN) carcinogenicity. In experiment 1, 6-7-week-old p53 (+/-) and p53 (+/+) mice were treated with 0, 0.025 and 0.05% DBN, respectively, in drinking water for 20 weeks....

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Identifiers

PMID: 12706858
DOI: 10.1016/s0304-3835(03)00057-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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