Article

Functional Human Genes Typically Exhibit Epigenetic Conservation

2021-06-02

Abstract excerpt

Recent DepMap CRISPR-Cas9 single gene disruptions have identified genes more essential to proliferation in tissue culture. It would be valuable to translate these finding with measurements more practical for human tissues. Here we show that DepMap essential genes and other literature curated functional genes exhibit cell-specific preferential epigenetic conservation when DNA methylation measurements are compared b...

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Literature Corpus work: a3dd8782-5ba2-5bb2-b281-f187aadabf29
DOI: 10.1101/2021.06.02.446759

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