Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.

doi:10.1016/j.stem.2012.02.013

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Article

Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives.

Cell stem cell - 4 May 2012

Nazor Kristopher L, Altun Gulsah, Lynch Candace, Tran Ha, Harness Julie V, Slavin Ileana, Garitaonandia Ibon, Müller Franz-Josef, Wang Yu-Chieh, Boscolo Francesca S, Fakunle Eyitayo, Dumevska Biljana, Lee Sunray, Park Hyun Sook, Olee Tsaiwei, D'Lima Darryl D, Semechkin Ruslan, Parast Mana M, Galat Vasiliy, Laslett Andrew L, Schmidt Uli, Keirstead Hans S, Loring Jeanne F, Laurent Louise C

Abstract excerpt

Human pluripotent stem cells (hPSCs) are potential sources of cells for modeling disease and development, drug discovery, and regenerative medicine. However, it is important to identify factors that may impact the utility of hPSCs for these applications. In an unbiased analysis of 205 hPSC and 130 somatic samples, we identified hPSC-specific epigenetic and transcriptional aberrations in genes subject to X...

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Identifiers

PMID: 22560082
DOI: 10.1016/j.stem.2012.02.013
PMCID: PMC3348513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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