Article
Genetic interactions of separase regulatory subunits reveal the diverged Drosophila Cenp-C homolog.
Genes & development - 1 Sept 2005
Heeger Sebastian, Leismann Oliver, Schittenhelm Ralf, Schraidt Oliver, Heidmann Stefan, Lehner Christian F
Abstract excerpt
Faithful transmission of genetic information during mitotic divisions depends on bipolar attachment of sister kinetochores to the mitotic spindle and on complete resolution of sister-chromatid cohesion immediately before the metaphase-to-anaphase transition. Separase is thought to be responsible for sister-chromatid separation, but its regulation is not completely understood. Therefore, we have screened for...
Topics
- Animals
- Animals, Genetically Modified
- Cell Cycle Proteins
- Centromere
- Chromosomal Proteins, Non-Histone
- Drosophila
- Drosophila Proteins
- Endopeptidases
- Eye Abnormalities
- Genes, Insect
- Kinetochores
- Mitosis
- Mutation
- Phenotype