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Article

Identification of sisters separate (ssep), a gene required for meiotic centromere cohesion in Drosophila melanogaster.

Genetics - 10 Dec 2025

Hewitt Sanay T, Pellizzari Sarah, Thornton Sean, Ward Hallet S, Hylton Christopher A, Keat Aaron, Shore Charlotte, Onuzulike Yolanda, Giri Bishwa K, Tomkiel Dean John E

Abstract excerpt

Cohesins regulate attachment between sister chromatids in both mitosis and meiosis. In Drosophila, two complexes of cohesins have been identified that have been proposed to differentially affect arm cohesion and centromere cohesion. We describe sisters separate (ssep), a newly identified gene required for meiotic sister chromatid cohesion. We demonstrate that ssep corresponds to CG30383, a previously...

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PMID: 41100682
DOI: 10.1093/genetics/iyaf222

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