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Article

Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells.

Chromosoma - 1 Feb 2008

Gause Maria, Webber Hayley A, Misulovin Ziva, Haller Gabe, Rollins Robert A, Eissenberg Joel C, Bickel Sharon E, Dorsett Dale

Abstract excerpt

Drosophila Nipped-B is an essential protein that has multiple functions. It facilitates expression of homeobox genes and is also required for sister chromatid cohesion. Nipped-B is conserved from yeast to man, and its orthologs also play roles in deoxyribonucleic acid repair and meiosis. Mutation of the human ortholog, Nipped-B-Like (NIPBL), causes Cornelia de Lange syndrome (CdLS), associated with multiple...

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Share to Chromatids
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17909832
DOI: 10.1007/s00412-007-0125-5
PMCID: PMC2258212

Genes

NIPBL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Functional links between Drosophila Nipped-B and cohesin in somatic and meiotic cells.PMID 17909832Read ↗

Drosophila Nipped-B Mutants Model Cornelia de Lange Syndrome in Growth and Behavior.Semantic proximity Read ↗

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Drosophila nipped-B protein supports sister chromatid cohesion and opposes the stromalin/Scc3 cohesion factor to facilitate long-range activation of the cut gene.Semantic proximity Read ↗

Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B.Semantic proximity Read ↗

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