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Article

Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition.

Cell - 12 Jan 1996

Stratmann R, Lehner C F

Abstract excerpt

Mutations in the Drosophila genes pimples and three rows result in a defect of sister chromatid separation during mitosis. As a consequence, cytokinesis is also defective. However, cell cycle progression including the mitotic degradation of cyclins A and B is not blocked by the failure of sister chromatid separation, and as a result, metaphase chromosomes with twice the normal number of chromosome arms still...

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PMID: 8548823
DOI: 10.1016/s0092-8674(00)80990-3

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