Article
The radially swollen 4 separase mutation of Arabidopsis thaliana blocks chromosome disjunction and disrupts the radial microtubule system in meiocytes.
PloS one - 29 Apr 2011
Yang Xiaohui, Boateng Kingsley A, Yuan Li, Wu Shuang, Baskin Tobias I, Makaroff Christopher A
Abstract excerpt
The caspase-family protease, separase, is required at the onset of anaphase to cleave the cohesin complex that joins replicated sister chromatids. However, in various eukaryotes, separase has acquired additional and distinct functions. A single amino-acid substitution in separase is responsible for phenotypes of the Arabidopsis thaliana mutant, radially swollen 4 (rsw4). This is a conditional mutant, resembling...
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