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Article

Core promoter-specific function of a mutant transcription factor TFIID defective in TATA-box binding.

Proceedings of the National Academy of Sciences of the United States of America - 5 Dec 1995

Martinez E, Zhou Q, L'Etoile N D, Oelgeschläger T, Berk A J, Roeder R G

Abstract excerpt

In conjunction with other general initiation factors, the TATA box-binding protein (TBP) can direct basal transcription by RNA polymerase II from TATA-containing promoters, but its stable interaction with TBP-associated factors (TAFs) in the TFIID complex is required both for activator-dependent transcription and for basal transcription directed by an initiator element. We have generated a TATA-binding-defective...

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Source

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Identifiers

PMID: 8524864
DOI: 10.1073/pnas.92.25.11864
PMCID: PMC40503

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Core promoter-specific function of a mutant transcription factor TFIID defective in TATA-box binding.PMID 8524864Read ↗

TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes.Semantic proximity Read ↗

A new regulatory domain on the TATA-binding protein.Semantic proximity Read ↗

Yeast and human TATA-binding proteins have nearly identical DNA sequence requirements for transcription in vitro.Semantic proximity Read ↗

Radical mutations reveal TATA-box binding protein surfaces required for activated transcription in vivo.Semantic proximity Read ↗

Transcription factor TFIIB sites important for interaction with promoter-bound TFIID.Semantic proximity Read ↗

Requirement for transcription factor IIA (TFIIA)-TFIID recruitment by an activator depends on promoter structure and template competition.Semantic proximity Read ↗

Direct recognition of initiator elements by a component of the transcription factor IID complex.Semantic proximity Read ↗

A regulated two-step mechanism of TBP binding to DNA: a solvent-exposed surface of TBP inhibits TATA box recognition.Semantic proximity Read ↗

Core promoter-dependent TFIIB conformation and a role for TFIIB conformation in transcription start site selection.Semantic proximity Read ↗

Mutations on the DNA binding surface of TBP discriminate between yeast TATA and TATA-less gene transcription.Semantic proximity Read ↗

Architecture of TAF11/TAF13/TBP complex suggests novel regulatory state in General Transcription Factor TFIID functionSemantic proximity Read ↗

The Drosophila TATA binding protein contains a strong but masked activation domain.Semantic proximity Read ↗

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