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Article

The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation.

Nucleic acids research - 1 Apr 2014

Posse Viktor, Hoberg Emily, Dierckx Anke, Shahzad Saba, Koolmeister Camilla, Larsson Nils-Göran, Wilhelmsson L Marcus, Hällberg B Martin, Gustafsson Claes M

Abstract excerpt

Mammalian mitochondrial transcription is executed by a single subunit mitochondrial RNA polymerase (Polrmt) and its two accessory factors, mitochondrial transcription factors A and B2 (Tfam and Tfb2m). Polrmt is structurally related to single-subunit phage RNA polymerases, but it also contains a unique N-terminal extension (NTE) of unknown function. We here demonstrate that the NTE functions together with Tfam to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24445803
DOI: 10.1093/nar/gkt1397
PMCID: PMC3973307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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