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Article

Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.

Journal of neuroscience research - 15 Oct 2005

Hyun Dong-Hoon, Lee Moonhee, Halliwell Barry, Jenner Peter

Abstract excerpt

Mutations in parkin are involved in some cases of autosomal recessive juvenile parkinsonism (AR-JP), but it is not known how they result in nigral cell death. We examined the effect of parkin overexpression on the response of cells to various insults. Wild-type and AR-JP-associated mutant parkins (Del3-5, T240R, and Q311X) were overexpressed in NT-2 and SK-N-MC cells. Overexpressed wild-type parkin delayed cell...

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Identifiers

PMID: 16130151
DOI: 10.1002/jnr.20638

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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