Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.

Journal of neurochemistry - 1 Feb 2001

Lee M, Hyun D, Halliwell B, Jenner P

Abstract excerpt

Mutations in alpha-synuclein (A30P and A53T) are involved in some cases of familial Parkinson's disease (FPD), but it is not known how they result in nigral cell death. We examined the effect of alpha-synuclein overexpression on the response of cells to various insults. Wild-type alpha-synuclein and alpha-synuclein mutations associated with FPD were overexpressed in NT-2/D1 and SK-N-MC cells. Overexpression of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehydes
Share to Culture Media, Serum-Free
Share to Glutathione

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ketones

Share to Lipid Peroxidation

Share to Oxidants

Share to Parkinsonian Disorders

Share to Synucleins

Source

Identifiers

PMID: 11181819
DOI: 10.1046/j.1471-4159.2001.00149.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.PMID 11181819Read ↗

Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults.Semantic proximity Read ↗

Dopamine auto-oxidation aggravates non-apoptotic cell death induced by over-expression of human A53T mutant alpha-synuclein in dopaminergic PC12 cells.Semantic proximity Read ↗

Differential effects of overexpression of wild-type and mutant human alpha-synuclein on MPP+-induced neurotoxicity in PC12 cells.Semantic proximity Read ↗

Induction of neuronal death by alpha-synuclein.Semantic proximity Read ↗

Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.Semantic proximity Read ↗

α-Synuclein overexpression increases dopamine toxicity in BE(2)-M17 cellsSemantic proximity Read ↗

Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopathogenesis of Parkinson's DiseaseSemantic proximity Read ↗

Dopamine-related and caspase-independent apoptosis in dopaminergic neurons induced by overexpression of human wild type or mutant alpha-synuclein.Semantic proximity Read ↗

Sensitization of neuronal cells to oxidative stress with mutated human alpha-synuclein.Semantic proximity Read ↗

Wild-type but not Parkinson's disease-related ala-53 --> Thr mutant alpha -synuclein protects neuronal cells from apoptotic stimuli.Semantic proximity Read ↗

Dopamine transporter-mediated cytotoxicity of 6-hydroxydopamine in vitro depends on expression of mutant alpha-synucleins related to Parkinson's disease.Semantic proximity Read ↗

The Parkinson disease-associated A30P mutation stabilizes alpha-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.