Article
Parkinson's disease genetic mutations increase cell susceptibility to stress: mutant alpha-synuclein enhances H2O2- and Sin-1-induced cell death.
Neurobiology of aging - 1 Nov 2007
Jiang Haibing, Wu Yen-Ching, Nakamura Masayuki, Liang Yideng, Tanaka Yuji, Holmes Susan, Dawson Valina L, Dawson Ted M, Ross Christopher A, Smith Wanli W
Abstract excerpt
Parkinson's disease (PD) is a progressive neurodegenerative movement disorder characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. Alpha-synuclein is a major component of Lewy bodies in sporadic PD, and genetic alterations in alpha-synuclein cause autosomal-dominant hereditary PD. The pathogenesis of PD remains incompletely understood, but it appears to involve both genetic...
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