Article
Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome.
The Journal of biological chemistry - 9 Aug 2002
Hyun Dong-Hoon, Lee MoonHee, Hattori Nobutaka, Kubo Shin-Ichiro, Mizuno Yoshikuni, Halliwell Barry, Jenner Peter
Abstract excerpt
Mutations in Parkin (a ubiquitin protein ligase) are involved in autosomal recessive juvenile parkinsonism, but it is not known how they cause nigral cell death. We examined the effect of Parkin overexpression on cellular levels of oxidative damage, antioxidant defenses, nitric oxide production, and proteasomal enzyme activity. Increasing expression of Parkin by gene transfection in NT-2 and SK-N-MC cells led to...
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