Article
Manganese-induced toxicity in normal and human B lymphocyte cell lines containing a homozygous mutation in parkin.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Oct 2012
Roth Jerome A, Ganapathy Balakrishnan, Ghio Andrew J
Abstract excerpt
Mutations in the parkin gene are linked to development of juvenile onset of Parkinson's disease and recent studies have reported that parkin can protect against increased oxidative stress and mitochondrial dysfunction caused by a variety of oxidative and toxic insults. Overexpression of parkin has also been reported to selectively protect dopaminergic neurons from Mn toxicity. Accordingly, in this paper we...
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