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Article

Cell-permeable parkin proteins suppress Parkinson disease-associated phenotypes in cultured cells and animals.

PloS one - 1 Jan 2014

Duong Tam, Kim Jaetaek, Ruley H Earl, Jo Daewoong

Abstract excerpt

Parkinson's disease (PD) is a neurodegenerative disorder of complex etiology characterized by the selective loss of dopaminergic neurons, particularly in the substantia nigra. Parkin, a tightly regulated E3 ubiquitin ligase, promotes the survival of dopaminergic neurons in both PD and Parkinsonian syndromes induced by acute exposures to neurotoxic agents. The present study assessed the potential of cell-permeable...

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Identifiers

PMID: 25019626
DOI: 10.1371/journal.pone.0102517
PMCID: PMC4097392

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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