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Article

Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.

Journal of neurochemistry - 1 Jun 2008

Hasegawa Takafumi, Treis Angela, Patenge Nadja, Fiesel Fabienne C, Springer Wolfdieter, Kahle Philipp J

Abstract excerpt

Parkinson's disease (PD) motor symptoms are caused by degeneration of nigrostriatal dopaminergic (DAergic) neurons. The most common causes of hereditary PD are mutations in the PARKIN gene. The ubiquitin ligase parkin has been shown to mediate neuroprotection in cell culture and in vivo, but the molecular mechanisms are not well understood. We investigated the effects of parkin in a human SH-SY5Y neuroblastoma...

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Source

Identifiers

PMID: 18248610
DOI: 10.1111/j.1471-4159.2008.05277.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Parkin protects against tyrosinase-mediated dopamine neurotoxicity by suppressing stress-activated protein kinase pathways.PMID 18248610Read ↗

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