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Article

Differential effects of Parkin and its mutants on protein aggregation, the ubiquitin-proteasome system, and neuronal cell death in human neuroblastoma cells.

Journal of neurochemistry - 1 Aug 2007

Kyratzi Elli, Pavlaki Maria, Kontostavlaki Dimitra, Rideout Hardy J, Stefanis Leonidas

Abstract excerpt

Mutations in Parkin, an E3 ligase, which participates in the ubiquitin-proteasome system (UPS), cause juvenile onset Parkinson's disease (PD). Some mutants aggregate upon over-expression, but the effects of such aggregation on the UPS and neuronal survival have not been characterized. We show in this study that transient over-expression of wild type (WT) Parkin or various mutants in human neuroblastoma cells...

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Identifiers

PMID: 17472700
DOI: 10.1111/j.1471-4159.2007.04620.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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