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Article

Generation of variability by in vivo recombination of halves of a (beta/alpha)8 barrel protein.

Biomolecular engineering - 1 Oct 2005

Saab-Rincón Gloria, Mancera Eugenio, Montero-Morán Gabriela, Sánchez Filiberto, Soberón Xavier

Abstract excerpt

Similar to what has been achieved with nucleic acids, directed evolution of proteins would be greatly facilitated by the availability of large libraries and efficient selection methods. So far, host cell transformation efficiency has been a bottleneck, practically limiting libraries to sizes less than 10(9). One way to circumvent this problem has been implemented with antibody systems, where contribution to the...

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PMID: 16125117
DOI: 10.1016/j.bioeng.2005.01.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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