Article
Accelerated protein engineering for chemical biotechnology via homologous recombination.
Current opinion in biotechnology - 1 Dec 2013
Nordwald Erik M, Garst Andrew, Gill Ryan T, Kaar Joel L
Abstract excerpt
Protein engineering has traditionally relied on random mutagenesis strategies to generate diverse libraries, which require high-throughput screening or selection methods to identify rare variants. Alternatively, approaches to semi-rational library construction can be used to minimize the screening load and enhance the efficiency by which improved mutants may be identified. Such methods are typically limited to...
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