Little evidence of reduced survival to adulthood of apoE epsilon4 homozygotes in Down's syndrome.

doi:10.1097/00001756-199711100-00010

Back to search

Article

Little evidence of reduced survival to adulthood of apoE epsilon4 homozygotes in Down's syndrome.

Neuroreport - 10 Nov 1997

Edland S D, Wijsman E M, Schoder-Ehri G L, Leverenz J B

Abstract excerpt

It has been proposed that homozygosity for the apolipoprotein E (apoE) epsilon4 allele decreases the probability of an individual with Down's syndrome (DS) surviving to adulthood. We performed a meta-analysis of 11 published DS series for which apoE genotype data were available. Seven epsilon4 ho...

Topics

Adolescent
Adult
Aged
Alleles
Apolipoprotein E4
Apolipoproteins E
Down Syndrome
Gene Frequency
Genotype
Homozygote
Humans
Middle Aged
Survival Rate

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.