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Article

Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.

The EMBO journal - 21 Sept 2005

Mizutani Akifumi, Wang Lei, Rajan Harini, Vig Parminder J S, Alaynick William A, Thaler Joshua P, Tsai Chih-Cheng

Abstract excerpt

Ataxin-1 is a neurodegenerative disorder protein whose glutamine-repeat expanded form causes spinocerebellar ataxia type 1 (SCA1) in humans and exerts cytotoxicity in Drosophila and mouse. We report here that the cytotoxicity caused by ataxin-1 is modulated by association with a related protein, Brother of ataxin-1 (Boat). Boat and ataxin-1 share a conserved AXH (ataxin-1 and HMG-box protein 1) domain, which is...

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Identifiers

PMID: 16121196
DOI: 10.1038/sj.emboj.7600785
PMCID: PMC1224676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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