Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2.

The Journal of biological chemistry - 5 Oct 2007

Bolger Timothy A, Zhao Xuan, Cohen Todd J, Tsai Chih-Cheng, Yao Tso-Pang

Abstract excerpt

Ataxin-1 is a neurodegenerative disorder protein whose mutant form causes spinocerebellar ataxia type-1 (SCA1). Evidence suggests that ataxin-1 may function as a transcription repressor. However, neither the importance of this putative transcriptional repression activity in neural cytotoxicity no...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxin-1
Share to Ataxins
Share to Cerebellum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chlorocebus aethiops

Share to Histone Deacetylases

Share to MEF2 Transcription Factors

Share to Myogenic Regulatory Factors

Share to Neurodegenerative Diseases

Source

Identifiers

PMID: 17646162
DOI: 10.1074/jbc.M704182200

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17646162-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The neurodegenerative disease protein ataxin-1 antagonizes the neuronal survival function of myocyte enhancer factor-2.PMID 17646162Read ↗

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors.Semantic proximity Read ↗

Histone deacetylases and their role in motor neuron degenerationSemantic proximity Read ↗

Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1Semantic proximity Read ↗

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.Semantic proximity Read ↗

Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1.Semantic proximity Read ↗

The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.Semantic proximity Read ↗

The deacetylase HDAC4 controls myocyte enhancing factor-2-dependent structural gene expression in response to neural activity.Semantic proximity Read ↗

TDP-43 knockdown impairs neurite outgrowth dependent on its target histone deacetylase 6Semantic proximity Read ↗

PML clastosomes prevent nuclear accumulation of mutant ataxin-7 and other polyglutamine proteins.Semantic proximity Read ↗

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.Semantic proximity Read ↗

RNA association and nucleocytoplasmic shuttling by ataxin-1.Semantic proximity Read ↗

Ataxin-2 promotes apoptosis of human neuroblastoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.