Article
Ataxin 2-binding protein 1 is a context-specific positive regulator of Notch signaling during neurogenesis in Drosophila melanogaster.
Development (Cambridge, England) - 1 Mar 2017
Shukla Jay Prakash, Deshpande Girish, Shashidhara L S
Abstract excerpt
The role of the Notch pathway during the lateral inhibition that underlies binary cell fate choice is extensively studied, but the context specificity that generates diverse outcomes is less well understood. In the peripheral nervous system of Drosophila melanogaster, differential Notch signaling between cells of the proneural cluster orchestrates sensory organ specification. Here we report functional analysis of...
Topics
- Animals
- Crosses, Genetic
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Membrane Proteins
- Neurogenesis
- Phenotype
- RNA-Binding Proteins
- Receptors, Notch
- Repressor Proteins
- Sense Organs
- Signal Transduction
- Transcription Factors