Article

SCA4 locus-associated gene Ronin (Thap11) increases Ataxin-1 protein levels and induces cerebellar degeneration in a mouse model of ataxia

2020-03-05

Abstract excerpt

<h4>ABSTRACT</h4> Spinocerebellar ataxias (SCAs) are a group of genetically heterogeneous inherited neurodegenerative disorders characterized by progressive ataxia and cerebellar degeneration. Here, we tested if Ronin (Thap11), a polyglutamine-containing protein encoded in a region on human chromosome 16q22.1 that has been genetically linked to SCA4, can be connected with SCA disease in a mouse model. We report t...

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Literature Corpus work: c81dca4e-1e7c-58bf-8a98-b75e257397a7
DOI: 10.1101/2020.03.04.977405

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SCA4 locus-associated gene Ronin (Thap11) increases Ataxin-1 protein levels and induces cerebellar degeneration in a mouse model of ataxiaDOI 10.1101/2020.03.04.977405Read

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