Article

Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1

2022-02-16

Abstract excerpt

<h4>Background: </h4> Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by a polyglutamine expansion in the ataxin-1 protein. The pathogenic mechanism resulting in SCA1 is still unclear. Protein-protein interactions affect the function and stability of ataxin-1. <h4>Methods: </h4>: Wild type and mutant ataxin-1 were expressed in HEK-293T cells. The levels of expression were assessed using...

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Literature Corpus work: f40a82a5-a7f7-56f8-a83d-beb281f751a0
DOI: 10.21203/rs.3.rs-1331134/v1

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