Article
Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity.
The Journal of cell biology - 5 Nov 2018
Mallik Moushami, Catinozzi Marica, Hug Clemens B, Zhang Li, Wagner Marina, Bussmann Julia, Bittern Jonas, Mersmann Sina, Klämbt Christian, Drexler Hannes C A, Huynen Martijn A, Vaquerizas Juan M, Storkebaum Erik
Abstract excerpt
Cabeza (caz) is the single Drosophila melanogaster orthologue of the human FET proteins FUS, TAF15, and EWSR1, which have been implicated in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. In this study, we identified Xrp1, a nuclear chromatin-binding protein, as a key modifier of caz mutant phenotypes. Xrp1 expression was strongly up-regulated in caz mutants, and Xrp1 heterozygosity rescued...
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