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Article

Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases.

Human molecular genetics - 1 Feb 2008

Branco Joana, Al-Ramahi Ismael, Ukani Lubna, Pérez Alma M, Fernandez-Funez Pedro, Rincón-Limas Diego, Botas Juan

Abstract excerpt

Spinocerebellar Ataxia type 1 (SCA1) and Huntington's disease (HD) are two polyglutamine disorders caused by expansion of a CAG repeat within the coding regions of the Ataxin-1 and Huntingtin proteins, respectively. While protein folding and turnover have been implicated in polyglutamine disorders in general, many clinical and pathological differences suggest that there are also disease-specific mechanisms....

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PMID: 17984172
DOI: 10.1093/hmg/ddm315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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