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Article

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors.

Proceedings of the National Academy of Sciences of the United States of America - 23 Mar 2004

Tsai Chih-Cheng, Kao Hung-Ying, Mitzutani Akifumi, Banayo Ester, Rajan Harini, McKeown Michael, Evans Ronald M

Abstract excerpt

Ataxin 1 (Atx1) is a foci-forming polyglutamine protein of unknown function, whose mutant form causes type 1 spinocerebellar ataxia in humans and exerts neurotoxicity in transgenic mouse and fly expressing mutant Atx1. In this study, we demonstrate that Atx1 interacts with the transcriptional corepressor SMRT (silencing mediator of retinoid and thyroid hormone receptors) and with histone deacetylase 3. Atx1 binds...

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Identifiers

PMID: 15016912
DOI: 10.1073/pnas.0400615101
PMCID: PMC384693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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