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Article

The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila.

Molecular brain - 13 Jul 2024

Baek Si-Eun, Kwon Younghwi, Yoon Jong-Won, Kim Hyo-Sung, Yang Jae-Yoon, Lee Dong-Seok, Yeom Eunbyul

Abstract excerpt

Dorsal switch protein 1(DSP1), a mammalian homolog of HMGB1, is firstly identified as a dorsal co-repressor in 1994. DSP1 contains HMG-box domain and functions as a transcriptional regulator in Drosophila melanogaster. It plays a crucial role in embryonic development, particularly in dorsal-ventral patterning during early embryogenesis, through the regulation of gene expression. Moreover, DSP1 is implicated in...

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Identifiers

PMID: 39003465
DOI: 10.1186/s13041-024-01117-2
PMCID: PMC11245852

Genes

HMGB1
TH

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