Article
Idiosyncratic tuning of tRNAs to achieve uniform ribosome binding.
Nature structural & molecular biology - 1 Sept 2005
Olejniczak Mikołaj, Dale Taraka, Fahlman Richard P, Uhlenbeck Olke C
Abstract excerpt
The binding of seven tRNA anticodons to their complementary codons on Escherichia coli ribosomes was substantially impaired, as compared with the binding of their natural tRNAs, when they were transplanted into tRNA(2)(Ala). An analysis of chimeras composed of tRNA(2)(Ala) and various amounts of either tRNA(3)(Gly) or tRNA(2)(Arg) indicates that the presence of the parental 32-38 nucleotide pair is sufficient to...
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