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Article

Alternative design of a tRNA core for aminoacylation.

Journal of molecular biology - 3 Nov 2000

Christian T, Lipman R S, Evilia C, Hou Y M

Abstract excerpt

The core of Escherichia coli tRNA(Cys) is important for aminoacylation of the tRNA by cysteine-tRNA synthetase. This core differs from the common tRNA core by having a G15:G48, rather than a G15:C48 base-pair. Substitution of G15:G48 with G15:C48 decreases the catalytic efficiency of aminoacylation by two orders of magnitude. This indicates that the design of the core is not compatible with G15:C48. However, the...

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Source

Identifiers

PMID: 11054287
DOI: 10.1006/jmbi.2000.4169

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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