Distinct ways of G:U recognition by conserved tRNA binding motifs.

doi:10.1073/pnas.1807109115

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Article

Distinct ways of G:U recognition by conserved tRNA binding motifs.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jul 2018

Chong Yeeting E, Guo Min, Yang Xiang-Lei, Kuhle Bernhard, Naganuma Masahiro, Sekine Shun-Ichi, Yokoyama Shigeyuki, Schimmel Paul

Abstract excerpt

Throughout three domains of life, alanyl-tRNA synthetases (AlaRSs) recognize a G3:U70 base pair in the acceptor stem of tRNAAla as the major identity determinant of tRNAAla The crystal structure of the archaeon Archaeoglobus fulgidus AlaRS in complex with tRNAAla provided the basis for G3:U70 recognition with residues (Asp and Asn) that are conserved in the three domains [Naganuma M, et al. (2014) Nature...

Topics

Alanine-tRNA Ligase
Escherichia coli
Escherichia coli Proteins
Humans
Models, Molecular
Mutation
Nucleotide Motifs
RNA, Transfer

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Identifiers

PMID: 29967150
DOI: 10.1073/pnas.1807109115
PMCID: PMC6055181

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