Aminoacylation of tRNA in the evolution of an aminoacyl-tRNA synthetase.

doi:10.1073/pnas.95.23.13495

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Article

Aminoacylation of tRNA in the evolution of an aminoacyl-tRNA synthetase.

Proceedings of the National Academy of Sciences of the United States of America - 10 Nov 1998

Lipman R S, Hou Y M

Abstract excerpt

Aminoacyl-tRNA synthetases catalyze aminoacylation of tRNAs by joining an amino acid to its cognate tRNA. The selection of the cognate tRNA is jointly determined by separate structural domains that examine different regions of the tRNA. The cysteine-tRNA synthetase of Escherichia coli has domains...

Topics

Acylation
Amino Acyl-tRNA Synthetases
Base Sequence
Escherichia coli
Evolution, Molecular
Humans
Molecular Sequence Data
Mutation
RNA, Transfer, Amino Acyl
Saccharomyces cerevisiae

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