Article
A strategy of tRNA recognition that includes determinants of RNA structure.
Bioorganic & medicinal chemistry - 1 Jun 1997
Hamann C S, Hou Y M
Abstract excerpt
Recognition of tRNAs by aminoacyl tRNA synthetases establishes the connection between amino acids and anticodon triplets of the genetic code. Although anticodons and nucleotides adjacent to the amino acid attachment site are generally important, the tertiary structural framework of tRNAs has recently been implicated to have a role in tRNA recognition. A G15:G48 tertiary hydrogen base pair of E. coli tRNA(Cys) is...
Topics
- Acetylation
- Amino Acyl-tRNA Synthetases
- Base Composition
- Base Sequence
- Escherichia coli
- Kinetics
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA Probes
- RNA, Transfer, Cys
- RNA, Transfer, Gly
- Structure-Activity Relationship
- Substrate Specificity
