Article
tRNA residues evolved to promote translational accuracy.
RNA (New York, N.Y.) - 1 Apr 2013
Shepotinovskaya Irina, Uhlenbeck Olke C
Abstract excerpt
The decoding properties of 22 structurally conservative base-pair and base-triple mutations in the anticodon hairpin and tertiary core of Escherichia coli tRNA(Ala)GGC were determined under single turnover conditions using E. coli ribosomes. While all of the mutations were able to efficiently decode the cognate GCC codon, many showed substantial misreading of near-cognate GUC or ACC codons. Although all the...
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