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p53-Dependent Transcriptional Repression of c-myc Is Required for G1 Cell Cycle Arrest

18 Aug 2005

Abstract excerpt

The ability of p53 to promote apoptosis and cell cycle arrest is believed to be important for its tumor suppression function. Besides activating the expression of cell cycle arrest and proapoptotic genes, p53 also represses a number of genes. Previous studies have shown an association between p53 activation and down-regulation of c-myc expression. However, the mechanism and physiological significance of...

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PMID: 16107691
DOI: 10.1128/mcb.25.17.7423-7431.2005

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p53-Dependent Transcriptional Repression of c-myc Is Required for G1 Cell Cycle ArrestPMID 16107691Read ↗

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