Article
Targeting of Miz-1 is essential for Myc-mediated apoptosis.
The Journal of biological chemistry - 10 Feb 2006
Patel Jagruti H, McMahon Steven B
Abstract excerpt
The c-Myc oncoprotein plays a central role in human cancer via its ability to either activate or repress the transcription of essential downstream targets. For many of the repressed target genes, down-regulation by c-Myc relies on its ability to bind and inactivate the transcription factor Miz-1. Although Miz-1 inactivation is suspected to be essential for at least some of the biological activities of c-Myc, it...
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