Article
Histone deacetylases specifically down-regulate p53-dependent gene activation.
The Journal of biological chemistry - 7 Jul 2000
Juan L J, Shia W J, Chen M H, Yang W M, Seto E, Lin Y S, Wu C W
Abstract excerpt
p53, the most commonly mutated gene in cancer cells, directs cell cycle arrest or induces programmed cell death (apoptosis) in response to stress. It has been demonstrated that p53 activity is up-regulated in part by posttranslational acetylation. In agreement with these observations, here we show that mammalian histone deacetylase (HDAC)-1, -2, and -3 are all capable of down-regulating p53 function....
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