Article
Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway.
The Journal of biological chemistry - 14 Jan 2005
Vaqué Jose P, Navascues Joaquin, Shiio Yuzuru, Laiho Marikki, Ajenjo Nuria, Mauleon Itsaso, Matallanas David, Crespo Piero, León Javier
Abstract excerpt
Even though RAS usually acts as a dominant transforming oncogene, in primary fibroblasts and some established cell lines Ras inhibits proliferation. This can explain the virtual absence of RAS mutations in some types of tumors, such as chronic myeloid leukemia (CML). We report that in the CML cell line K562 Ras induces p21Cip1 expression through the Raf-MEK-ERK pathway. Because K562 cells are deficient for...
Topics
- Cell Cycle Proteins
- Cell Division
- Cell Line, Tumor
- Cell Nucleus
- Cyclin-Dependent Kinase Inhibitor p21
- DNA-Binding Proteins
- Helix-Loop-Helix Motifs
- Humans
- K562 Cells
- Kruppel-Like Transcription Factors